Non-dissociative structural transitions of the Watson-Crick and reverse Watson-Crick А·Т DNA base pairs into the Hoogsteen and reverse Hoogsteen forms
نویسندگان
چکیده
منابع مشابه
Comparable Stability of Hoogsteen and Watson–Crick Base Pairs in Ionic Liquid Choline Dihydrogen Phosphate
The instability of Hoogsteen base pairs relative to Watson-Crick base pairs has limited biological applications of triplex-forming oligonucleotides. Hydrated ionic liquids (ILs) provide favourable environments for a wide range of chemical reactions and are known to impact the stabilities of Watson-Crick base pairs. We found that DNA triplex formation was significantly stabilized in hydrated cho...
متن کاملNon-Watson-Crick base pairs in RNA-protein recognition.
The cellular functions of most RNA molecules involve protein binding, and non-Watson-Crick base pairs are hallmark sites for interactions with proteins. The determination of three-dimensional structures of RNA-peptide and RNA-protein complexes reveals the molecular basis of non-Watson-Crick base-pair recognition.
متن کاملOn the propeller structure of isolated Watson-Crick base pairs.
The nucleotide sequence dependence of the DNA and RNA secondary structure is a problem of current interest in molecular biophysics. The key role of stacking interactions in determining this dependence is widely accepted [1, 2], It is be lieved that the propeller twisting of base pairs, ob served in the structure of both nucleic acids and crystals of nucleosides and nucleotides is a direct man...
متن کاملRole of Reverse Watson-Crick Purine-Purine Base Pairs in Functional RNAs
Identification of static and/or dynamic roles of different non-canonical base pairs is essential for a comprehensive understanding of the sequence-structure-function space of RNA. In the past combined structural bioinformatic and quantum mechanical (QM) approach provided insights into occurrence context and conservation and covariation pattern of non-canonical A:G W:W Cis base pair in RNAs. In ...
متن کاملHigher order structural effects stabilizing the reverse Watson–Crick Guanine-Cytosine base pair in functional RNAs
The G:C reverse Watson-Crick (W:W trans) base pair, also known as Levitt base pair in the context of tRNAs, is a structurally and functionally important base pair that contributes to tertiary interactions joining distant domains in functional RNA molecules and also participates in metabolite binding in riboswitches. We previously indicated that the isolated G:C W:W trans base pair is a rather u...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-28636-y